AAPS Workshop on Methods for Detecting
and Characterizing Sub-visible Particulates
Sunday, June 21, 2009
Washington State Convention and Trade
Center
Seattle, WA
8:00 am - 5:15 pm
Background Information:
Recently a great deal of
attention has been focused on the possible impact of particulates in biological
therapeutics. In particular, it has been recognized that there is a gap in
analysis of sub-visible particulates < 10 microns. While good methods exist
for detecting and characterizing the size distributions of very small (< 0.1
micron) particulates, there are fewer analogous techniques that provide
accurate size distributions for particulates in the 0.1 to 10 micron size
range.
Speakers and Topics to include
Steven J. Shire, Ph.D.
Genentech, Inc.
Current Sub-visible Particle-size Distribution
Technologies
Barthelemy Demeule, Ph.D.
University of Geneva and
University of Lausanne
Coulter Counter technologies
Matt Rhyner,
Ph.D.
Emory University
Beckman Instruments
Matt Rhyner,
Ph.D.
Light Obscuration Methods
Deepak K. Sharma, Ph.D.
Brightwell Technologies Inc.
Thomas M. Scherer, Ph.D.
University of Massachusetts
Wyatt
Technology, Inc.
John
Champagne
Amgen Inc.
Sampath Krishnan
Detailed Program information will be available at:
http://www.aapspharmaceutica.com/sub-visibleparticulates
Call +1 877- 998-AAPS or mailto:email meetings@aaps.org for more
information.
Prior workshops:
Reform School for
Ill-Behaved Proteins, July 2008
Allen Minton, National Institutes of Health
“New light scattering method for detection and characterization of protein association in highly concentration solution”
Jun Liu, Genentech, Inc.
“Misbehaving Proteins – A Perspective from Biopharmaceutical Industry”
C.Russ Middaugh,
“The Polyanion World and Ill-Behaved Proteins”
Christopher J. Roberts,
“What controls non-native aggregation of foldable Proteins? Competing views from polymer physics, colloid science, and protein chemistry”
Yatin Gokarn, Amgen, Inc.
“Good Proteins, Bad Environment: Role of Effective Charge in Governing Stability, Solubility & Rheology”
Thomas Malia, Centocor, Inc.
“Refolding of soluble and membrane proteins: methods and structural characterization”
Characterizing the Physical Properties of Purified Antibodies, July 2007
Sandra Smith-Gill, National Cancer Institute, NIH
“Thermodynamics and time-dependent stability of antibody-antigen complexes”
Steve Shire, Genetech, Inc.
“Monoclonal antibody viscosity and self-association: analytics and interpretation of results”
Nick Pace,
“Protein stability and solubility: contribution of net charge and individual amino acid side chains”
Wayne Bolen,
“Relating protein-osmolyte interactions to Protein solubility and stability”
Eric Sundberg,
“Energetic cooperativity in protein-protein interactions”
Innovations in
Analytical Ultracentrifugation and Surface Plasmon Resonance: Advanced Instruments and Analysis Software, July 2004
Fluorescence detection optical system for the analytical ultracentrifuge: data acquisition and analysis, operating system and simulation software.
Biacore’s surface plasmon resonance biosensor (3000): advance techniques and GPCR studies.
Walter Stafford,
David Myszka,
Thomas Laue, Center to Advance Molecualr Itneraction Science
Simon Cocklin,
Kenneth Miller and Brian Lang, Biacore
Fluorescence
Spectroscopy of Ligan Binding, July 2003
Joe Beechem, Molecular Probes: HTS assays
Zygmunt Gryczynski, Center for fluorescence Spectrosocpy: General principles, polarization, new developments
Nancy Thompson, U.
James Foley, Rowland Institute, Harvard: Fluorescent dyes
Curve Fitting and
Data Analysis, July 2002
Norma Greenfied, UNJMD, circular dichroism
Tom Laue, CAMIS, sedimentation equilibrium
Ernst Linder, UNH, generalized curve fitting
David Myszka, U. Utah, surface plasmon resonance
John Philo, Alliance Protein, sedimentation velocity