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Research Projects
Guidelines for Proposals
Current Projects
■ Microfluidic Characterization of Sub-Visible Particles, Glenn Walker, North Carolina State University ■ Dynamic Modeling of Protein-Protein Interactions in High-Concentration Biological Systems, John Tsavalas, University of New Hampshire ■ Characteristics and applications of membrane nanodiscs, Thomas M. Laue, University of New Hampshire ■ Brewster angle straddle interferometry for high throughput binding assays, Lewis Rotheberg, University of Rochester ■ Evaluation of a membrane confined electrophoresis device, Thomas M. Laue, University of New Hampshire ■ Development of a high-precision vapor pressure osmometer for investiating biomolecular interactions, Jeffrey Hoch, University of Connecticut ■ Origin of altered thermograms in plasma from diseased individuals, Jonathan B. Chaires, University of Louisville ■ Interpreting fluorescence detected sedimentation for mAb interactions in serum, Thomas M. Laue, University of New Hampshire
Ongoing Projects
■ Educational resources: workshops, roundtable discussions, web-based
Completed Projects
■ Construction of a prototype fluorescence detector for the analytical ultracentrifuge, Thomas M. Laue, University of New Hampshire ■ Development of software for real-time display and analysis of sedimentation velocity software, Walter F. Stafford, Boston Biomedical Research Institute ■ Web-based computer aided itnerpretation of analytical sedimentation data, Thomas M. Laue, University of New Hampshire with David Hayes, Magdalen College and John Philo, Alliance Protein Laboratories ■ Analytical ultracentrifugation as a method for identifying and characterizing Src-containing multi-protein complexes in cance cells, Robert Vallari and Stephen Tobin, Saint Anselm College ■ High-throughput, high-precision absorbance data acquisition of biomolecular interactions, Thomas M. Laue, University of New Hampshire ■ Development of AUC fluorescence methods for hetero-protein interactions, John J. Correia, University of Mississippi Medical Center ■ Development of software for real-time display and analysis of sedimentation velocity data, Walter F. Stafford, Boston Biomedical Research Center ■ Development of a capillary centerpiece for the analytical ultracentrifuge fluorescence detection system, ■ Testing, validation and assay development for a new coupled plasmon waveguide resonance biosensor, David Myszka, University of Utah School of Medicine ■ Capture and reconstitution of G-protein coupled receptors on biosensor surfaces, David Myszka, University of Utah School of Medicine ■ A Disposable Polymeric Microdevice for Energetic Characterization of Biomolecular Interactions, Qiao Lin, Columbia University ■ Detection of protein binding and protein conformational changes by surface plasmon coupled emission, Karol Gryczynski, Health Science Center Unviersity of North Texas ■ Cause, consequence and manipulation of mAb valence, Thomas M. Laue, University of New Hampshire
■ A novel calorimetric assay for studies od drug-plasma protein interactions, Jonathan B. Chaires, University of Louisville ■ Quantitative FRET microscopy measurement of protein-protein interactions in vivo, Kenneth A. Christenson, Clemson University ■ Applications of atomic force microscopy for the analysis of biomolecular interactions, Vincent T. Moy, University of Miami |
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