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Electronic registration will begin on June 19th .  Online Registration



2014 Biomolecular Interactions Technology Center Symposium

 Hosts: University of New Hampshire & University of Delaware 

Monday, 4 August

Embassy Suites Hotel, Newark, DE 19711


Information for registration and hotel will be sent out later this week.


8:30 – 9:00 Breakfast


9:00 – 9:15 Welcome & opening remarks


9:15 – 9:45  John Tsavalas, University of New Hampshire, “Multimer protein cluster structure at high concentration: dynamic modeling of stability and viscosity


9:45 – 10:15  Eric Furst, University of Delaware, "Protein solution microrheology"


10:15 – 10:45 Jeremy Schmit, Kansas State University, “Simple models of antibody solution viscosity


10:45 – 11:00 Break


11:00 – 11:30  Michael Brenowitz, Albert Einstein College of Medicine – “Mapping molecular interfaces


11:30 – 12:00  Ed Lyman, University of Delaware, “Understanding how lipids modulate G-protein coupled receptors with theory and molecular simulation


12:00 – 12:30  Neil Lewis, Malvern Instruments, “Combining raman spectroscopy and dynamic light scattering for developing unique insights into protein structure and stability


12:30 – 1:30  Lunch


1:30 – 2:00  Abraham Lenhoff, University of Delaware, “Characterization by scattering methods of protein phases in downstream processing and formulations


2:00 – 2:30 Steven R. Aubuchon & Paulius Vaitiekunas, TA Instruments, “Calorimetric studies of biomolecular interactions


3:00 – 3:30  John Champagne, Wyatt Technologies,  “From mobility to stability: light scattering solutions for formulating stable biotherapeutics


3:30 – 4:00  Wrap-up


4:30 – 5:30 Poster session + additional discussion


6:30 PM  Dinner & Keynote Seminar

Keynote Speaker:  Allen Minton, National Institutes of Health, “Detection and quantitative characterization of macromolecular heteroassociation by composition gradient - sedimentation equilibrium








MONDAY JULY 22, 2013 




Dana Aswad, Professor of Molecular Biology and Biochemitry, School of Biological Sciences, University of Callifornia, Irvine

"Isoaspartate Formation:  Effects on Protein Structure and Function"


 Dr. Roy Jefferis, Professor Emeritus:  Molecular Immunology, Univeristy of Birmingham UK

"Structural and functional propfiles of protein and glycoform engineered human IgG"


Brian Baker, Associate Professor and Director of Graduate Studies, University of Notre Dame

"Molecular Flexibilty in T Cell Receptor of Antigen"


Tom Patapoff, Ph.D., Staff Scientist, Genentech, Inc., S. San Francisco, CA  

"Elucidation of Antibody Motion Using All Atom Molecular Dynamics"


Floyd Romersberg, Associate Professor, Department of Chemistry, California Campus, The Scripps Research Institute

The Evolution of Immunological Molecular Recognition


Steven J. Shire, Ph.D., Staff Scientist and Group Leader,  

Late Stage Pharmaceutical and Processing Development Dept., Genentech, Inc., S. San Francisco, CA

"Impact of Protein Conformation and Flexibility on Asp Isomerization Rates"


Joerg Zimmerman, Research Association, California Campus, The Scripps Research Institute

The Jiggling and Wiggling - Quantification of Antibody Flexibility "






Prior Workshops:

Monday July 16th, 2012 will be the Summer BITC Symposium

Antibodies in Solution

on the campus of the University of New Hampshire in Durham, New Hampshire

Anuj Chaudhri, University of Chicago: "Self-Association of Therapeutic Monoclonal Antibodies:  A Coarse-Grained Perspective on the Role of  Electrostatics and More"

Kenneth Christensen, Clemson University: "Capillary-channeled polymer fibers and nanofiber yarns as a platform for detection of biomolecular interactions"

Thomas Laue, University of New Hampshire:  "Methods for Charge Measurement"

Chris Roberts, University of Delaware:  "Protein interactions from low to high concentrations:  new approaches via scattering and protein engineering"

Peter Tessier, Rensselaer Polytech:  "Engineering aggregation-resistant antibodies"

John Tsavalas, University of New Hampshire:  "Dynamic Protein-Protein Interaction Modeling in Highly Concentrated Solutions:  Rheology and Stability"

Sandeep Yadav, Genentech:  "The Significance of Molecular Charge in Various Aspects of Product Development:  Can we Afford to Overlook it"

Monday July 11, 2011 to Thursday July 14, 2011

 The Advanced Analytical Ultracentrifugation Workshop: Theory and Practice

          on the campus of The University of New Hampshire in Durham, New Hampshire  -- 

  Daily Program Schedule                  map of Durham/UNH

Analytical Ultracentrifugation (AUC) is a powerful method for the determination of absolute molar mass, shape and for the analysis of reversible interactions and irreversible aggregation formation involving macromolecules in solution.  A combination of modern instrumentation, fast computers and new data analysis algorithms has led to an ever increasing use of AUC in basic research, process development and biotherapeutic formulations.

This is an advanced AUC workshop and is appropriate for academic and industrial scientists who are already familiar with basic experimental and data analysis methods.

Symposium Day:  Thursday, July 14th was a "Symposium Day".  This day was included in the registration for the workshop, but could also be registered for separately.

Instructors included:   Please click on the instructors name (or just below their names) for their presentations.

  • Walter Stafford, PhD, Senior Scientist and Director of Analytical Ultracentrifugation Research Lab at the Boston Biomedical Research Institutes in Watertown, MA
  • Thomas Laue, PhD, Professor and Director of the Biomolecular Interactions Technologies Center at the University of New Hampshire in Durham NH
  • AUC past/present presentation, macromolecule presentation, equilibrium presentation, high concentration presentation, optical systems presentation
  • John Philo, PhD, Director of Biophysical Chemistry at Alliance Protein Laboratories in Thousand Oaks, CA
  • James Cole,  PhD, Associate Professor in the Department of Molecular & Cell Biology at the University of Connecticut in Storrs, CT
  • Jack Correia, PhD, Professor in the Department of Biochemistry at the University of Mississippi Medical Center in Jackson, MS.

Symposium Day speakers will include:

  • John Tsavalas, PhD, University of New Hampshire
  • Richard Neubig, PhD, University of Michigan
  • Jeffrey Hoch, PhD, University of Connecticut Health Center
  • Vincent Moy, PhD, University of Miami
  • Lewis Rothberg, PhD, University of Rochester
  • Bin Wang, Columbia University
  • Sergio Aragon, PhD, San Francisco State University


       Bioassays:  The Good, The Bad and The Ugly! - July 2010

           Mark Chiu, Abbott Laboratories

           Thomas Glass, Sapidyne Instruments, Inc.

           Stephen Krause, MedImmune

           Jean Lee, Amgen Inc.

            Eric D. Roush, GE Healthcare    

            Bruce Thompson, Pfizer     

            Mohammed Yousef, Bio-Rad


  • AAPS Workshop on Methods for Detecting and Characterizing Sub-visible Particulates, June 2009

Steven J. Shire, Ph.D., Genentech, Inc.

Barthelemy Demeule, Ph.D.,University of Geneva and University of Lausanne

Matt Rhyner, Ph.D. Beckman Coulter Inc.

John Champagne, Wyatt Technology Inc

Sampath Krishnan, Amgen Inc.

Thomas M. Scherer, Ph.D., University of Massachusetts

Deepak K. Sharma, Ph.D., Brightwell Technologies Inc.

  • Reform School for Ill-Behaved Proteins, July 2008

Allen Minton, National Institutes of Health

“New light scattering method for detection and characterization of protein association in highly concentration solution”

Jun Liu, Genentech, Inc.

“Misbehaving Proteins – A Perspective from Biopharmaceutical Industry”

C.Russ Middaugh, University of Kansas

“The Polyanion World and Ill-Behaved Proteins”

Christopher J. Roberts, University of Delaware

“What controls non-native aggregation of foldable Proteins? Competing views from polymer physics, colloid science, and protein chemistry”

Yatin Gokarn, Amgen, Inc.

“Good Proteins, Bad Environment: Role of Effective Charge in Governing Stability, Solubility & Rheology”

Thomas Malia, Centocor, Inc.

“Refolding of soluble and membrane proteins: methods and structural characterization”

  • Characterizing the Physical Properties of Purified Antibodies, July 2007

Sandra Smith-Gill, National Cancer Institute, NIH

“Thermodynamics and time-dependent stability of antibody-antigen complexes”

Steve Shire, Genetech, Inc.

“Monoclonal antibody viscosity and self-association: analytics and interpretation of results”

Nick Pace, Texas A & M University

“Protein stability and solubility: contribution of net charge and individual amino acid side chains”

Wayne Bolen, University of Texas Medical Branch

“Relating protein-osmolyte interactions to Protein solubility and stability”

Eric Sundberg, Boston Biomedical Research Institute

“Energetic cooperativity in protein-protein interactions”

  • Innovations in Analytical Ultracentrifugation and Surface Plasmon Resonance: Advanced Instruments and Analysis Software, July 2004

Fluorescence detection optical system for the analytical ultracentrifuge: data acquisition and analysis, operating system and simulation software.

Biacore’s surface plasmon resonance biosensor (3000): advance techniques and GPCR studies.

Walter Stafford, Boston Biomedical Research Institute

David Myszka, University of Utah

Thomas Laue, Center to Advance Molecualr Itneraction Science

Simon Cocklin, Drexel University

Kenneth Miller and Brian Lang, Biacore

  • Fluorescence Spectroscopy of Ligan Binding, July 2003

Joe Beechem, Molecular Probes: HTS assays

Zygmunt Gryczynski, Center for fluorescence Spectrosocpy: General principles, polarization, new developments

Nancy Thompson, U. North Carolina: TIRF

James Foley, Rowland Institute, Harvard: Fluorescent dyes

  • Curve Fitting and Data Analysis, July 2002

Norma Greenfied, UNJMD, circular dichroism

Tom Laue, CAMIS, sedimentation equilibrium

Ernst Linder, UNH, generalized curve fitting

David Myszka, U. Utah, surface plasmon resonance

John Philo, Alliance Protein, sedimentation velocity



Listing of workshops and roundtables sponsored by BITC

2011 Roundtable:  "Methods used to determine higher order structural changes in protein biotherapeutics"

Date and location:  March 17th, 2011; South San Francisco CA


Steven Berkowitz, BiogenIdec  "The Use of Hydrogen/Deuterium Exchange-Mass Spectrometry (H/DX-MS) in the Biopharmaceutical Industry"

Stephen Harding, University of Nottingham "Hydrodynamic conformation and aggregation of antibodies and larger glycoconjugates"

Yen-Hue Lin,  Human Genome Sciences "Qualification of Biophysical Methods and use with Analytical Comparability Assessments"

David Volkin, University of Kansas "Protein particulates/aggregates and empirical phase diagrams to characterize 2/3 structure of proteins"




Workshops and Roundtables:

2010 Workshop:  Bioassays: The Good, The Bad and The Ugly!

2010 Roundtable: Microviscosity

2009 Workshop:  AAPS Workshop on Methods for Detecting and Characterizing Sub-visible Particles

2009 Roundtable: High Throughput Calorimetry

2008 Workshop: Reform School for Ill Behaving Proteins

2008 Roundtable:  Discussion on Comparability

2007 Workshop:  Characterizing the Physical Properties of Purified Antibodies

2007 Roundtable:  What's New in SPR?

2006 Workshop:  Membrane Protein Interactions

2006 Roundtable:  Innovations in Surface Technologies

2005 Roundtable:   FTIR and Raman Spectroscopy Applications in Drug Discovery

2004 Workshop:  Innovations in Analytical Ultracentrifugation and Surface Plasmon Resonance

2004 Roundtable: Quantum Dot Technologies  in Pharmaceutical Research

2003 Workshop;  Fluorescence Spectroscopy of Ligan Binding

2003 Roundtable:  Atomic Force Microscopy in Pharmaceutical Applications

2002 Workshop:  Curve Fitting and Data Analysis


University of New Hampshire

BITC's two-day workshops are conducted by leading scientists.
Gain extensive hands-on training in small groups.
Registration is limited. Plan now to attend.

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