Electronic registration will begin on June 19th . Online Registration
2014 Biomolecular Interactions Technology Center Symposium
Monday, 4 August
Embassy Suites Hotel, Newark, DE 19711
Information for registration and hotel will be sent out later this week.
8:30 – 9:00 Breakfast
9:00 – 9:15 Welcome & opening remarks
9:15 – 9:45 John Tsavalas, University of New Hampshire, “Multimer protein cluster structure at high concentration: dynamic modeling of stability and viscosity”
9:45 – 10:15 Eric Furst, University of Delaware, "Protein solution microrheology"
10:15 – 10:45 Jeremy Schmit, Kansas State University, “Simple models of antibody solution viscosity”
10:45 – 11:00 Break
11:00 – 11:30 Michael Brenowitz, Albert Einstein College of Medicine – “Mapping molecular interfaces”
11:30 – 12:00 Ed Lyman, University of Delaware, “Understanding how lipids modulate G-protein coupled receptors with theory and molecular simulation”
12:00 – 12:30 Neil Lewis, Malvern Instruments, “Combining raman spectroscopy and dynamic light scattering for developing unique insights into protein structure and stability”
12:30 – 1:30 Lunch
1:30 – 2:00 Abraham Lenhoff, University of Delaware, “Characterization by scattering methods of protein phases in downstream processing and formulations”
2:00 – 2:30 Steven R. Aubuchon & Paulius Vaitiekunas, TA Instruments, “Calorimetric studies of biomolecular interactions”
3:00 – 3:30 John Champagne, Wyatt Technologies, “From mobility to stability: light scattering solutions for formulating stable biotherapeutics”
3:30 – 4:00 Wrap-up
4:30 – 5:30 Poster session + additional discussion
6:30 PM Dinner & Keynote Seminar
Keynote Speaker: Allen Minton, National Institutes of Health, “Detection and quantitative characterization of macromolecular heteroassociation by composition gradient - sedimentation equilibrium”
SUMMER 2013 BITC SYMPOSIUM
MONDAY JULY 22, 2013
ANTIBODY FLEXIBILITY: IMPACT ON PROPERTIES AND FUNCTION
SPEAKERS TO INCLUDE:
Dana Aswad, Professor of Molecular Biology and Biochemitry, School of Biological Sciences, University of Callifornia, Irvine
"Isoaspartate Formation: Effects on Protein Structure and Function"
Dr. Roy Jefferis, Professor Emeritus: Molecular Immunology, Univeristy of Birmingham UK
"Structural and functional propfiles of protein and glycoform engineered human IgG"
Brian Baker, Associate Professor and Director of Graduate Studies, University of Notre Dame
"Molecular Flexibilty in T Cell Receptor of Antigen"
Tom Patapoff, Ph.D., Staff Scientist, Genentech, Inc., S. San Francisco, CA
"Elucidation of Antibody Motion Using All Atom Molecular Dynamics"
Floyd Romersberg, Associate Professor, Department of Chemistry, California Campus, The Scripps Research Institute
“The Evolution of Immunological Molecular Recognition”
Steven J. Shire, Ph.D., Staff Scientist and Group Leader,
Late Stage Pharmaceutical and Processing Development Dept., Genentech, Inc., S. San Francisco, CA
"Impact of Protein Conformation and Flexibility on Asp Isomerization Rates"
Joerg Zimmerman, Research Association, California Campus, The Scripps Research Institute
" The Jiggling and Wiggling - Quantification of Antibody Flexibility "
Monday July 16th, 2012 will be the Summer BITC Symposium
Antibodies in Solution
on the campus of the University of New Hampshire in Durham, New Hampshire
Anuj Chaudhri, University of Chicago: "Self-Association of Therapeutic Monoclonal Antibodies: A Coarse-Grained Perspective on the Role of Electrostatics and More"
Kenneth Christensen, Clemson University: "Capillary-channeled polymer fibers and nanofiber yarns as a platform for detection of biomolecular interactions"
Thomas Laue, University of New Hampshire: "Methods for Charge Measurement"
Chris Roberts, University of Delaware: "Protein interactions from low to high concentrations: new approaches via scattering and protein engineering"
Peter Tessier, Rensselaer Polytech: "Engineering aggregation-resistant antibodies"
John Tsavalas, University of New Hampshire: "Dynamic Protein-Protein Interaction Modeling in Highly Concentrated Solutions: Rheology and Stability"
Monday July 11, 2011 to Thursday July 14, 2011
on the campus of The University of New Hampshire in Durham, New Hampshire --
Analytical Ultracentrifugation (AUC) is a powerful method for the determination of absolute molar mass, shape and for the analysis of reversible interactions and irreversible aggregation formation involving macromolecules in solution. A combination of modern instrumentation, fast computers and new data analysis algorithms has led to an ever increasing use of AUC in basic research, process development and biotherapeutic formulations.
This is an advanced AUC workshop and is appropriate for academic and industrial scientists who are already familiar with basic experimental and data analysis methods.
Symposium Day: Thursday, July 14th was a "Symposium Day". This day was included in the registration for the workshop, but could also be registered for separately.
Instructors included: Please click on the instructors name (or just below their names) for their presentations.
Symposium Day speakers will include:
Bioassays: The Good, The Bad and The Ugly! - July 2010
Mark Chiu, Abbott Laboratories
Thomas Glass, Sapidyne Instruments, Inc.
Stephen Krause, MedImmune
Jean Lee, Amgen Inc.
Eric D. Roush, GE Healthcare
Bruce Thompson, Pfizer
Mohammed Yousef, Bio-Rad
Steven J. Shire, Ph.D., Genentech, Inc.
Barthelemy Demeule, Ph.D.,University of Geneva and University of Lausanne
Matt Rhyner, Ph.D. Beckman Coulter Inc.
John Champagne, Wyatt Technology Inc
Sampath Krishnan, Amgen Inc.
Thomas M. Scherer, Ph.D., University of Massachusetts
Allen Minton, National Institutes of Health
“New light scattering method for detection and characterization of protein association in highly concentration solution”
Jun Liu, Genentech, Inc.
“Misbehaving Proteins – A Perspective from Biopharmaceutical Industry”
“The Polyanion World and Ill-Behaved Proteins”
Christopher J. Roberts,
“What controls non-native aggregation of foldable Proteins? Competing views from polymer physics, colloid science, and protein chemistry”
Yatin Gokarn, Amgen, Inc.
“Good Proteins, Bad Environment: Role of Effective Charge in Governing Stability, Solubility & Rheology”
“Refolding of soluble and membrane proteins: methods and structural characterization”
Sandra Smith-Gill, National Cancer Institute, NIH
“Thermodynamics and time-dependent stability of antibody-antigen complexes”
Steve Shire, Genetech, Inc.
“Monoclonal antibody viscosity and self-association: analytics and interpretation of results”
“Protein stability and solubility: contribution of net charge and individual amino acid side chains”
“Relating protein-osmolyte interactions to Protein solubility and stability”
“Energetic cooperativity in protein-protein interactions”
Fluorescence detection optical system for the analytical ultracentrifuge: data acquisition and analysis, operating system and simulation software.
Biacore’s surface plasmon resonance biosensor (3000): advance techniques and GPCR studies.
Thomas Laue, Center to Advance Molecualr Itneraction Science
Kenneth Miller and Brian Lang, Biacore
Joe Beechem, Molecular Probes: HTS assays
Zygmunt Gryczynski, Center for fluorescence Spectrosocpy: General principles, polarization, new developments
Nancy Thompson, U.
James Foley, Rowland Institute, Harvard: Fluorescent dyes
Norma Greenfied, UNJMD, circular dichroism
Tom Laue, CAMIS, sedimentation equilibrium
Ernst Linder, UNH, generalized curve fitting
David Myszka, U. Utah, surface plasmon resonance
John Philo, Alliance Protein, sedimentation velocity