RESEARCH INTERESTS
The research in my laboratory is directed toward the development of direct physical methods for determining properties of macromolecules, including mass, charge, size, shape, and solubility, as well as the state of aggregation and the extent of ligand binding. Along with standard optical methods (absorbance, fluorescence, circular dichroism), our lab has developed novel instrumentation for sedimentation analysis (both equilibrium and velocity) and charge analysis (steady state electrophoresis). These methods are being applied to a wide range of macromolecular interaction s of importance, including those in blood coagulation, DNA transcriptional regulation, viral DNA integration, and gel formation. Moreover, we are now studying the contribution of macromolecular charge to structure, stability, and assembly through a unique combination of physical methods.