Research Projects

 

Guidelines for Proposals
Request for Proposals

 

Current Projects

 

■ Brewster angle straddle interferometry for high throughput binding assays.

■ A Disposable Polymeric Microdevice for Energetic Characterization of Biomolecular Interactions.

■ Detecting mAb aggregates in serum.

■ Development of AUC fluorescence methods for hetero-protein interactions.

■ Detection of protein binding and protein conformational changes by surface plasmon coupled emission.

■ Web-based computer aided interpretation of analytical sedimentation data.

■ Development of software for real-time display and analysis of sedimentation velocity software.

■ Analytical ultracentrifugation as a method for identifying and characterizing Src-containing multi-protein complexes in cancer cells.

■ High-throughput, high-precision absorbance data acquisition for the analytical ultracentrifuge.

 

Ongoing Projects

 

■ Educational resources:  workshops, roundtable discussions, web-based Technical Resource Center.

 

Completed Projects

 

■ Construction of a prototype fluorescence detector for the analytical ultracentrifuge.

■ Testing, validation and assay development for a new coupled plasmon waveguide resonance biosensor.

■ Capture and reconstitution of G-protein coupled receptors on biosensor surfaces.

■ Multiplexed quantitation and screening via flow cytometry protein interaction assay.

■ Quantitative FRET microscopy measurement of protein-protein interactions in vivo.

■ Applications of atomic force microscopy for the analysis of biomolecular interactions.