Research Projects
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Current Projects
■ Brewster angle straddle interferometry for high throughput binding assays.
■ A Disposable Polymeric Microdevice for Energetic Characterization of Biomolecular Interactions.
■ Detecting mAb aggregates in serum.
■ Development of AUC fluorescence methods for hetero-protein interactions.
■ Detection of protein binding and protein conformational changes by surface plasmon coupled emission.
■ Web-based computer aided interpretation of analytical sedimentation data.
■ Development of software for real-time display and analysis of sedimentation velocity software.
■ Analytical ultracentrifugation as a method for identifying and characterizing Src-containing multi-protein complexes in cancer cells.
■ High-throughput, high-precision absorbance data acquisition for the analytical ultracentrifuge.
Ongoing Projects
■ Educational resources: workshops, roundtable discussions, web-based
Completed Projects
■ Construction of a prototype fluorescence detector for the analytical ultracentrifuge.
■ Testing, validation and assay development for a new coupled plasmon waveguide resonance biosensor.
■ Capture and reconstitution of G-protein coupled receptors on biosensor surfaces.
■ Multiplexed quantitation and screening via flow cytometry protein interaction assay.
■ Quantitative FRET microscopy measurement of protein-protein interactions in vivo.
■ Applications of atomic force microscopy for the analysis of biomolecular interactions.